Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury
نویسندگان
چکیده
منابع مشابه
P24: Minimally Conscious State Improvements with Thalamic Ventralis Intermedius Nucleus Stimulation after Severe Traumatic Brain Injury
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متن کاملp24: minimally conscious state improvements with thalamic ventralis intermedius nucleus stimulation after severe traumatic brain injury
methods of modulating brain neural plasticity, improving memory and learning, improving recovery from traumatic brain injury, preventing epilepsy, treating memory disorders, and treating persistent impairment of consciousness in humans and animals by nerve stimulation are provided. widespread loss of cerebral connectivity is assumed to underlie the failure of brain mechanisms that support commu...
متن کاملThe Effects of Cyclooxygenase Inhibitors on the Brain Inflammatory Response Following Traumatic Brain Injury in Rats
Objective(s) Cytokines such as IL-1β are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1β after traumatic brain injury (TBI) in male rats. Materials and Methods Rats were assigned into 6 groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations ...
متن کاملTargeting Dopamine in Acute Traumatic Brain Injury.
In addition to the initial mechanical damage, traumatic brain injury (TBI) induces a series of secondary insults, such as, but not limited to, excitotoxicity, metabolic disruption, and oxidative stress. Neuroprotective strategies after TBI have traditionally focused on cellular preservation as the measurable endpoint although multiple lines of evidence indicate that even with significant neuron...
متن کاملCerebral response to speech in vegetative and minimally conscious states after traumatic brain injury.
PRIMARY OBJECTIVE To study cerebral response in a functional magnetic resonance imaging (fMRI) task of speech perception in a sample of patients in vegetative state (VS) and minimally conscious state (MCS) after traumatic brain injury. METHODS Three patients in VS, four patients in MCS and 19 healthy volunteers were enrolled for the study. All subjects underwent an fMRI task of passive listen...
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ژورنال
عنوان ژورنال: Brain
سال: 2019
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awz118